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Tuliv Migraine Library

    The Migraine Cycle

    In order to understand the process of migraines, you first need to realize that you get migraines because of a particular gene you inherited. It is that gene that affects the way your body manages hormone fluctuations. Although this is easier to see in the case of women, it holds true for men as well.

    After years of research we created the Migraine Occurrence Model (MOM).

    This model helped map the path to our discovery of how migraines could be prevented. We had long suspected that in order to get migraines, a person must inherit a gene in the DNA from the maternal side of the family. This gene, the methylenetetrahydrofolate reductase gene (MTHFR) variant C677T, has been identified as the one that influences susceptibility to migraines.

    The “migraine gene” is found in the mitochondria of specific hormone-producing cells that receive their "production orders" from the pituitary gland by way of hormone-receptors located on the membranes of these cells. These orders come in the form of protein hormones called glycoproteins. The luteinizing hormone (LH) and follicle-stimulating hormone (FSH) instruct cells to produce progesterone, estrogen, or testosterone.

    The Problem

    The migraine syndrome begins within the cells containing MTHFR gene when they cause the synthesis of an adverse neurochemical called CGRP to be released into the blood stream.

    CGRP causes the dilation of the blood vessels in the trigeminal-vascular system that makes the head hurt. This combination of nerves and blood vessels is located on both sides of the head and extends behind the eyes and into the face.

    The Pain

     As the blood vessels, intertwined with the nerve endings, begin to dilate and swell, the pressure from the swelling blood vessels puts throbbing pressure on the tiny nerve fibers. This pressure is felt as headache pain. Migraine pain generally starts around the temple area and moves forward along the line of the trigeminal nerve, behind the eyes surrounding the sinus cavity, and down the jaw line.

    Temporary Relief

    Triptans, such as Imitrex, constrict dilated blood vessels to relieve the pressure and abort the migraine. These drugs are designed to stop the pain, but they do nothing to prevent the return of another migraine. They provide temporary relief from pain, but Tuliv researchers knew there had to be a better way.

    Our research into the cause of migraines led to a solution for the prevention of migraines. By identifying the natural cause of migraines we were able to produce a natural product to reduce and prevent the occurrences of migraines.

    Natural Migraine Prevention

    Tuliv Migraine Defense is a proactive approach to migraine treatment, preventing migraines rather than only seeking to eliminate the pain of an already-triggered migraine.

    Tuliv Migraine Defense is the only anti-migraine product that builds a natural defense system in your body to keep migraines from occurring.

    Migraine Defense neither adds to nor depletes the body of any hormones. The purpose of Migraine Defense is to manage the problem that causes migraines. Therefore, Migraine Defense is safe for use by men, women, and children.

    See References.

    We believe in providing you with personal care and service.

    Call toll free 1-866-367-5953 to personally visit with a migraine specialist (outside the US and Canada call 1-405-692-4395). All calls are considered personal and confidential. There is no cost or obligation for your call.

    You can also visit with us by email at

The Tuliv Migraine Library has the information you need from A to Z

Tuliv Ltd. Co. Oklahoma City, OK 73189-1466

Toll Free: 1-866-367-5953
Outside USA: 1-405-692-4395